CBD May Actually Increase THC’s Intoxicating Effect, New Marijuana Study Finds, Contrary To Conventional Wisdom

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A recent study examining the combined effects of THC and CBD suggests that, contrary to widespread belief, CBD may actually heighten the experience of a marijuana high rather than diminishing it.

The research, published in the journal Clinical Pharmacology and Therapeutics, found that people who took a high dose of CBD (450 mg) alongside a smaller, 9-mg dose of THC “did not reduce, but instead significantly increased subjective, psychomotor, cognitive, and autonomous effects of THC.”

Smaller doses of CBD, such as 10 mg and 30 mg, did not appear to have the same effect.

The findings are noteworthy in part because conventional wisdom among many in the cannabis community is that CBD can help lessen a too-intense marijuana high by blocking THC’s interaction with the brain’s CB1 receptors. The study suggests that at some level, CBD in fact begins to make the felt effects of cannabis more intense.

A seven-person research team in the Netherlands and the U.S. authored the new report, which looked at the results of a randomized, double-blind, placebo-controlled trial involving 37 healthy volunteers.

The team was attempting to test the hypothesis that CBD would reduce the adverse effects of THC. If confirmed, they believed the effect could help make therapeutic THC more tolerable for chronic pain patients by reducing the substance’s psychoactive effects.

Evidence, however, showed the opposite effect. Moreover, the addition of CBD did not appear to produce any additional pain-relieving effects.

“These results provide evidence against the hypothesis that CBD attenuates THC effects, highlight the potential for drug interactions even at low doses of CBD, and add to the understanding of THC analgesia,” authors wrote in the report.

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